AMLODIPINE BESYLATE LOADED POLYMERIC NANOPARTICLES: PREPARATION AND IN VITRO CHARACTERISATION

Objective: The present investigation aims to formulate the ideal drug formulation using different surfactants and optimize amlodipine-loaded polymeric nanoparticles. Methods: work was drug-loaded nanoparticles enhance dissolution rate of a poorly water-soluble drug, amlodipine besylate, anti-solvent precipitation method. Characterisation studies include particle size (nm), Zeta potential (mV), polydispersity index, Drug entrapment efficiency (%), in vitro release release, surface morphological like SEM XRD. Results: Polymeric F3 containing PLGA PVA shows desired smaller is 198.8±5.25, maximum zeta is-24.76±2.54 mv stable index 0.957±0.45. 93%, controlled pattern about 94.88±2.45 24h. Conclusion: observed that PNs significantly improved character besylate. have can be used as suitable delivery carrier for low solubility bioavailable drugs improve its rate.